17-18 May 2022
Online
Asia/Tehran timezone
شرکت‌کنندگان گرامی، علیرغم تعطیلی اضطراری تهران در روز سه‌شنبه ٢٧ اردیبهشت، دوازدهمین همایش کاربران چشمه نور ایران مطابق با برنامه‌ی از پیش اعلام شده، کماکان به شکل مجازی برگزار خواهد شد.

دفتر آموزش و توسعه کاربران چشمه نور ایران

Structural Biology at Diamond Light Source: What Have We Learnt About Covid-19?

May 18, 2022, 3:30 PM
40m
Online

Online

in English

Speaker

Dr Armin Wagner (I23 Principal Beamline Scientist, Diamond Light Source)

Description

Macromolecular crystallography (MX) has been the most successful synchrotron technique contributing to several Nobel prices in Chemistry and Physiology or Medicine. The atomic models obtained as results of the diffraction experiments give detailed structural insight into the function of proteins, nucleic acids and their complexes. It has become an important tool in basic science and drug design and the public protein data bank (PDB) contains now more than 165,000 X-ray structures. In recent years cryo-electron microscopy (EM) has undergone several technical advances and can now also provide very accurate structural models for large complexes. While not a synchrotron radiation-based method, many Light Sources run dedicated EM facilities as part of their user programs.
In my presentation I will give an overview on the facilities available for structural biology at Diamond Light Source. In addition, I will highlight several projects in which both MX and EM have contributed to the understanding of the receptor binding of the spike protein of SARS-CoV-2 and work towards COVID-19 drugs inhibiting the main protease (MPRO) of this virus.

Presentation materials

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